|
KMID : 1123920190330010063
|
|
Korean Journal of Oriental Physiology and Pathology
2019 Volume.33 No. 1 p.63 ~ p.67
|
|
|
Cosmetic Potency of Puerariae Radix in Dermal Fibroblasts
|
|
Lee Jae-Yun
Park Seo-A
Woo Won-Hong
Mun Yeun-Ja
|
|
|
Abstract
|
|
|
|
Interaction between epidermis and dermis plays an important role in wound healing and hair follicle formation. This study focused on investigating the potency of ethanol extract of Puerariae Radix (EPR) as cosmetic ingredient using human dermal fibroblasts (hDFn). Our results revealed that EPR suppressed collagenase activity dose-dependently. EPR inhibited activity of 5α-reductase I and II at the final concentration of 25 μg/ml in hDFn cells. Also, EPR promoted the proliferation and the ERK activation of cells. ERK phosphorylation by EPR was blocked by specific inhibitor of ERK, PD98059. EPR-induced cell proliferation was blocked by PD98059. This means that EPR could promote the proliferation of hDFn cells via the activation ERK. Collectively, these results suggest that EPR may be used as a new cosmetic ingredient.
|
|
|
KEYWORD
|
|
|
Pureraria Lobata, Collagenase, 5α-reductase, ERK, Dermal fibroblast
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|